what company manufactures colchicine - A New Gout Drug. Febuxostat wins marketing approval in the European Union
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A New Gout Drug. Febuxostat wins marketing approval in the European Union

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.


And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.


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  NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

Recent research has shown that vitamin C lowers uric acid level but whether this means something in patients with gout is not clear. Avoiding medication that cause gout such as diuretics or "water pills" or adjusting doses after discussing with the healthcare provider can also help.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.

Herbal remedies for gout have become very popular in recent years. There is very little evidence right now that shows alternative therapies are effective for gout. Uricinex is a breakthrough herbal product that we have recently discovered. Blueberries are high in anti-inflammatory compounds called anthocyanins, which help ease the pain of gout. Other herbal treatments that have shown some success include vitamin C - Taking supplemental amounts of vitamin C helps some people to reduce the uric acid in their blood. Taking 2-3 teaspoons of black cherry juice a day helps some people. Cherries are a popular home remedy for gout.

To prevent future attacks, your doctor can prescribe a medicine to reduce uric acid buildup in your blood. Changing the way you eat can help you conduct your gout. Eat a healthy mix of foods so you get the nutrients you need. Limit foods like meat, fish, and beer. Drink plenty of water and other fluids.Life style changes such as limiting alcohol consumption, and limiting meals with meats and fish rich in purines can also be helpful in controlling gout. Weight loss may be very important this condition. You should also avoid certain animal proteins, such as: seafood; liver; kidney; heart; gizzard; sweetbreads; meat extracts; and gravy.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

Decreasing the intake of alcohol is also helpful since alcohol affects the elimination of uric acid. Although the effect of foods that cause gout is only small it must not be forgotten. Meat and seafood are common causes of gout if taken in excess.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

Gout is one of the most common forms of arthritis (joint inflammation). Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout usually affects the first metatarsal phalangeal joint of the big toe (hallux) or the ankle joints. Gout most often affects the big toe but can also affect the ankle, knee, foot, hand, wrist and elbow. Approximately one million people in the United States suffer from attacks of gout. Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause.

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Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

It occurs more frequently in countries that have a high standard of living. The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe. There may also be the feeling that the skin around the area is stretching or tearing. There seem to be a number of factors that can cause people to develop gout. Some medications can prevent uric acid from leaving the body. Cyclosporine which is a medication used to suppress the body's immune system and prevent rejection after organ transplant, also increases the risk for developing gout. This can cause a build up of uric acid crystals.

 
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Gout is a painful and sudden illness that can affect joints. It is caused by the accumulation of excess uric acid, which is normally removed through the urine. The crystals of uric acid can then accumulate in joints and cause inflammation and pain. Often patients are not able to get to their healthcare provider right away. If it is a first attack the symptoms can be alarming. Fortunately, it is rarely life threatening and often resolves in a few days even without treatment. However everyone who gets an attack should see their healthcare provider since there are many excellent treatments available. But what can one do while at home?

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

Diagnosing a gout case can be very difficult sometimes. However, there are a few procedures that will help your doctor diagnose gout. Here are some of the medical investigations that you doctor will suggest ti diagnose gout: - a blood test is maybe the first procedure that has to be made in diagnosing gout; a blood test can measure the urate level that you have in your blood; urate is the main cause of gout; however, a person can still have high urate levels in his/ her blood and still not suffer from gout; when raised levels of urate appear in the blood, this can indicate that you have gout, but this can also be caused by other medical conditions or medication that a person takes; furthermore, a person can have normal levels of urate in his/ her body during a gout attack; - after a blood test that can give doctors an idea whether you can have gout or not, to be more sure and to be able to diagnose a gout case, doctors will examine the fluid that is found in your joints; this fluid can be extracted from your joints with the help of a needle; this can show you if indeed you suffer from gout or not; the fluid is then looked at under a microscope and if there are urate crystals( they indicate gout) , then they will be spotted right away; if indeed these crystals of urate are found in your joints, then, the blood test was right and you actually suffer from gout; this examination is not at all painful and it is very useful if your gout case starts very unusual; for example, a gout case can sometimes be mistaken for another rheumatic disease, like rheumatoid arthritis and gout can mimic this diseases very well; - another investigation that can be made to diagnose a gout case is x- ray; x- rays of your joints can betaken to see whether you suffer from gout or not, but unfortunately in most of the cases, everything will appear normal and your doctor will not be able to tell if you have gout or not;

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

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Alcohol and certain foods can trigger a gout attack. Events such as strokes, heart attacks or surgery may also cause gout. Gout is strongly associated with obesity, hypertension, hyperlipidemia and diabetes. Because of genetic factors, gout tends to run in some families. A variety of treatments can help you manage your gout. Traditionally treatment for acute gout has consisted of colchicine , which can be effective if given early in the attack. Gout often is treated with nonsteroidal anti-inflammatories (NSAIDs) such as naproxen (e.g., Anaprox, Naprosyn) and indomethacin (e.g., Indocin), usually for 3-7 days.

Gout is a form of rheumatism that can also lead to arthritis. It is a very painful medical condition that mostly affects men of all ages. Gout can also be found in women, but mostly those who have reached menopause.

The home remedy can include NSAID's but you may want to get a diagnosis first since other conditions can cause joint swelling including other forms of arthritis such as osteoarthritis and rheumatoid arthritis. Sometimes a joint infection can also look like gout especially if it is hot and red and swollen. If it is quite clear that it is gout, especially if it has affected a joint before, local ice and heat may be applied if comfortable. Taking an NSAID will help as long as the side effects are kept in mind which include stomach ulcer formation and at times high blood pressure. Some examples of NSAIDs are ibuprofen, naproxen and indomethacin.

If you are intersted in finding more information about gout you can click on this website http://www.gout-info-center.com. Also you will find there valuable information about gout treatments and gout diet.


 
 
     
 
 





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