what is allopurinol prescribed for - Review of Uricinex
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Review of Uricinex

Uricinex claims to reduce, and sometimes completely eliminate pain and swelling caused by gout. It does this thanks to a proprietary blend that reduces the level of Uric Acid. Micronutra, the makers of Uricinex, claims that this is all achieved naturally, without the side effects of prescription drugs. In addition, Urinex touts a high level of success, shown in an independent clinical study.


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Gout is a common, painful form of arthritis. Gout is a condition in which the body has a problem in the handling of uric acid. Uric acid is a waste product that naturally occurs in the body. It is normally flushed from the body by the kidneys through urine. It causes swollen, red, hot and stiff joints. Gout occurs when uric acid builds up in your blood. Men are more likely to get gout than women are, but women become increasingly susceptible to gout after menopause. Gout usually attacks the big toe however, it also can affect other joints such as the ankle, heel, instep, knee, wrist, elbow, fingers, and spine.

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There are several conditions that can result in gout, but the primary cause is an abnormally high level of uric acid in the blood, either from the body's producing too much or from the body's not excreting it properly. Gout is more common in men than in women, possibly because the female body eliminates uric acid more efficiently. The disease often strikes middle-aged males, especially men who are overweight and drink too much alcohol. But healthy people can develop gout, too. For instance, allowing yourself to become severely dehydrated may trigger an attack.

In some cases, the condition may appear in the joints of small toes that have become immobile due to impact injury earlier in life, causing poor blood circulation that leads to gout. It occurs more frequently in countries that have a high standard of living. Approximately one million people in the United States suffer from attacks of gout. Gout affects up to 500,000 Canadians. Men who develop gout usually do so between the ages of 30 and 50. Women are more likely to develop gout after the age of 60. The most common type of medicine used to treat an acute attack of gout is nonsteroidal anti-inflammatory drugs.

4. Take a nonprescription anti-inflammatory. Inflammation causes swelling, which worsens pain. Both ibuprofen and aspirin are anti-inflammatories, but when taken at low levels, aspirin may actually make the pain worse, so reach for the ibuprofen when treating gout.

Think of turf toe (hallux limitus) as an isolated case of osteoarthritis limited to the first MPJ. Whether the injury is acute or due to repetitive loading, the result is a load that is applied to the subchondral bone that is greater than what the bone can tolerate. As the injury progresses, a series of micro fractures will develop in the subchondral bone. The typical soft spongy character of the metaphyseal bone changes to become brittle and hard. The result is that the articular cartilage looses its' underlying support and becomes susceptible to damage. Juxtachondral eburnation, osteophytes, lipping, spurring; call them what you like, but what you see on your x-ray is the slow progressive destruction of the joint.

Other conditions - synovitis, crystal deposition diseases such as gout, systemic arthritis, external physical influences such as Dupytren's contracture, etc.

Gout comes on very suddenly, produces severe pain, and usually lasts three to five days if untreated. However, flare-ups frequently recur and last even longer.

But before we go any further, we need to understand that the terms turf toe and hallux limitus aren't really synonymous. The fundamental difference between the two terms is the patient population that they affect. Turf toe is a term used in athletic circles referring to any injury of the great toe joint. Consequently, discussions about turf toe will focus on the first two causes of hallux limitus mentioned above; functional hallux limitus and direct physical injury. On the other hand, when we discuss hallux limitus, we're actually referring to a broader, 'non-athletic' patient population and need to include all three causes of hallux limitus.

These drugs help reduce the pain and swelling of joints and decrease stiffness. If you think that diet acts as a trigger for your gout attacks, changing your diet may help, but it is important to talk to your healthcare provider about choosing the right diet for you. Gout diet prevention consists of a prevention diet low purine or modified purine diet may help gout improve. Gout diet prevention puts and emphasis on dairy products, vegetable protein and water intake and a decrease in high purine foods. A low-purine gout diet is often prescribed for individuals with gout. Purine is a compound that is mainly found in animal protein which is metabolized to uric acid in the body.

What's the actual physical change that takes place in the joint with turf toe? As an easy analogy, consider the changes that takes place when an apple falls from a height and is damaged. The skin of the apple appears intact but the underlying pulp is damaged. In the case of turf toe (hallux limitus), think of the skin of the apple as the cartilage of the joint and the damaged pulp of the apple is the subchondral bone. Mild cases of turf toe (hallux limitus), result in little damage to the subchondral bone and will merely exhibit signs of inflammatory change within the joint. Most authors would refer to these cases as stage one turf toe (hallux limitus). More severe cases result in damage to the joint surface, the subchondral bone or both. These are the stage two and three cases of turf toe (hallux limitus) that show visible change on x-ray. As the subchondral bone becomes increasingly damaged, it will create an uneven supporting surface for the cartilage. An increase in activity results in uneven loading of the joint due to the compression injury of the subchondral bone.

Nomenclature: First MPJ - the big toe joint Metatarsus primus elevatus - a functional or structural position of the first metatarsal First metatarsal - the foot bone making up the proximal portion of the big toe joint Hallux - the great toe

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So how does Uricinex stack up against its own claims? According to numerous testimonials, Uricinex does provide relief, sometimes within 72 hours. This pain relief appears to be caused by liquefying the crystallized uric acid that has formed in the joints. This is the cause of pain for gout sufferers. This liquid uric acid can then be expelled through urination. So on this count, Uricinex does appear to be very legitimate.

Unger, K., Rahimi, F., Bareither, D., Muehleman, C. The Relationship Between Articular Cartilage Degeneration and Bone Changes of the First Metatarsophalangeal Joint. J. Foot Surg. 39:1 24-33, 2000

Uricinex boasts an all-natural composition with no side effects. From a partial list of ingredients on the company's website, the main ingredients are derived from Yucca (a plant), Artichokes, Turmeric (a member of the ginger family), and Sylmarin (Milk Thistle). These ingredients are indeed natural. However the complete list of ingredients is not available for review. As for the side effects, research into similar products shows that a very small percentage of users (one half of 1%) have manor upset stomach symptoms. They are told to take the supplements with a meal to alleviate this problem. Again, this has not been reported for Uricinex, but for similar products on the market. The number of affected people is so small and not directly attributed to Uricinex use that we can believe the claim.


Differential Diagnosis: The differential diagnosis of turf toe includes; Arthitis Fracture Gout Joint infection Joint or bone tumor Synovitis

The most common symptom of gout, which afflicts about three-quarters of gout sufferers, is excruciating pain in the joint at the base of the big toe. However, joints in other parts of the body including the feet, hands, wrists, knees, shoulders, and elbows are fair game for gout attacks. Joints can become so swollen and inflamed that the patient develops a fever and chills.

When treating turf toe be sure to recognize the fact that there is no nerve innervation in articular cartilage. Pain associated with stage one turf toe (hallux limitus) is either synovial pain or bone pain. If we recognize that painful stage one turf toe (hallux limitus) may be due to bone pain, we then realize that turf toe should be treated aggressively to insure the long term viability of the joint.

 
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5. Avoid icing or heating the area. Unlike other types of pain, gout doesn't respond well to heat or ice therapy. 6. Wear comfortable shoes. For gout sufferers, styles that offer a lot of room for the toes are the best choice.

About the author:
Jeffrey A. Oster, DPM, C.Ped is a board certified foot and ankle
surgeon. Dr. Oster is also board certified in pedorthics. Dr.
Oster is medical director of href=http://www.myfootshop.comMyfootshop.com and is
in active practice in Granville, Ohio.


Anatomy: The great toe joint, or first metatarsal joint consists of two bones. The proximal bone is the first metatarsal and the distal is called the proximal phalanx or hallux. These two bone move against each other in an up and down motion through what we refer to as the sagital plane. Biomechanics: The motion of the great toe joint is dependant upon the plantarflexion of the first metatasal. If the first metatarsal is limitied in its' ability to plantarflex, the joint will jam resulting in funtional hallux limitus, which as we know is one of the causes of turf toe.

Turf toe caused by a direct injury to the joint may or may not be obvious. Athletes may not remember an incident of pain since they're often distracted by the event or game in which they're involved. The onset of direct injury to the joint may be abrupt, but also may be insidious becoming increasingly more painful as the season progresses. The joint pain will subside with rest only to recur with increased activity. It's not unusual to see symptoms of turf toe resolve in the off season only to recur with renewed exercise.

Is the onset of turf toe always the same? Turf toe that is the result of functional hallux limitus is going to be insidious in onset. Functional hallux limitus will usually be seen in younger athletes as they attempt to increase their activity. It may not occur during the first athletic season, or the second, but when it does begin to cause pain, the onset will be more frequent and more severe, varying with activity. This profile of onset is simply due to the fact that the athlete is recreating the injury with every step.

2. Keep the joint elevated. Let gravity help reduce inflammation by slowing the rush of blood to the gout inflicted joint. 3. Immobilize the joint. The less you move the joint, the better it will feel. Simply lying still will help, though you may want to build a splint for the injured joint. Ask your doctor how, or consult a first-aid guide.

Ronconi, P., Monachino, P., Baleanu, P.M.,Favilli, G. Distal Oblique Osteotomy of the First Metatarsal for the Correction of Hallux Limitus and Rigidus Deformity. J. Foot Surg. 39:3, 154-160, 2000

References: Lombardi, C.M., Silhanek, A.D., Connolly, F.G., Dennis, L.N., Keslonsky, A.J. First Metatarsophalangeal Arthrodesis for Treatment of Hallux Rigidus: A Retrospective Study. J. Foot Surg. 40:3, 137-143, 2001

Micronutria uses a 30-day independent clinical study as support for its effectiveness. The study claims that people who took two pills, three times a day reported positive results 97.7 % of the time. 94.2% reported that their pain was completely done. While these are impressive numbers, it is important to note that only 36 people took part in this study. This is by no means an exhaustive research into the benefits and possible side effects of Uricinex. More should be done to validate the claims made about this product.

Treatment of turf toe varies with the type of healthcare provider and includes the use of rest, shoe modifications, orthotics, steroid injections and surgery. The success of non-surgical care will vary with the degree of injury, the rate at which the injury is healing and how much osteoarthritis has occurred. We see varying degrees of success with orthotics that promote plantarflexion of the first ray, effectively treating metatarsus primus elevatus and peroneus longus dysfunction. Simple arch supports can make a significant difference in the symptoms of turf toe. Should our patient not respond to conservative care in a reasonable time period, we are not reluctant to suggest surgical revision to address the problem whether it be revisions of the joint defect, shortening of a long first metatarsal or structural revision of metatarsus primus elevatus. As mentioned before, the clinical appearance of dorsal lipping or visible radiographic changes are suggestive of moderately advanced osteoarthritis, a condition that is only repaired by joint revision or replacement.

Functional hallux limitus - biomechanical function that results in metatarsus primus elevatus and subsequent repetitive jamming of the first MPJ. Direct physical injury - injury to the articular cartilage or subchondral bone. These injuries may be due impaction injuries or hyperextension/flexion of the first MPJ.


Symptoms: Turf toe that is the result of functional hallux limitus is going to be insidious in onset. Functional hallux limitus will usually be seen in younger athletes as they attempt to increase their activity. It may not occur during the first athletic season, or the second, but when it does begin to cause pain, the onset will be more frequent and more severe, varying with activity. This profile of onset is simply due to the fact that the athlete is recreating the injury with every step. Turf toe caused by a direct injury to the joint may or may not be obvious. Athletes may not remember an incident of pain since they're often distracted by the event or game in which they're involved. The onset of direct injury to the joint may be abrupt, but also may be insidious becoming increasingly more painful as the season progresses. The joint pain will subside with rest only to recur with increased activity. It's not unusual to see symptoms of turf toe resolve in the off season only to recur with renewed exercise.

1. Don't put any weight on the joint. This usually means staying off your feet as much as possible until the episode subsides. Any pressure you put on the joint will increase the pain and possibly damage the area further.

This quick review has outlined a few of the key points to look for when considering Uricinex as a supplement for gout pain relief. Most of its claims appear to be legitimate and the product seems to do exactly what it claims. More research should be done to backup the claims, but in general, I recommend Uricinex.

Sufferers from gout, a debilitating and painful condition, often take several prescription medicines to combat this disease. These medications often leave patients with side effects that include impaired liver functions. Many of those afflicted by gout turn to natural supplements to replace/enhance their prescription treatments. Uricinex is one of the most popular of these natural supplements.

Turf toe gets no respect. Let's take a closer look at the causes of turf toe and see how to treat it more effectively. Turf toe is actually a form of hallux limitus. Hallux limitus is classically described as pain and progressive decrease in the range of motion of the first metatarsal phalangeal joint (MPJ). The onset of hallux limitus is due to the following:

Although gout produces brutal pain, it is rarely life-threatening. However, the condition requires proper diagnosis and treatment by a doctor, who can rule out other causes of joint pain and prescribe effective medications. Once you've seen your physician, however, there are a few things you should do on your own.


A low-purine diet and medications are commonly used to treat gout. Purines are mostly found in foods which are high in protein and fat content. For breakfast, take low-fat protein foods. High-protein foods that are low in fat have been found to be safe. Include lemon juice at lunch for cleansing. Lemon juice is filled with vitamin C and antioxidants to help flush your body from unwanted uric acids. Grilled or baked lean meat, wrapped foil to retain moisture, is ideal for dinner. Pair with potatoes and steamed spinach. After dinners make sure to have a bowl of cherries, berries or grapes on the side.


 
 
     
 
 





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Turf toe gets no respect. Let s take a closer look at the causes of turf toe and see how to treat it more effectively. Turf toe is actually a form of hallux limitus. Hallux limitus is classically described as pain and progressive decrease in the range of motion of the first metatarsal phalangeal joint (MPJ). The onset of hallux limitus is due to the following: Functional hallux limitus -...


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