Gout Sufferers - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
Gout Remedy Natural Gout Treatment Treat Gouts Naturally
 

New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.


Save 40% Off The Retail Price

People Said About Goutezol Gout Relief
"week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago
gout treatment


 HOW PEGLOTICASE WORKS

What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS

Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It has been having a decent degree of success.

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

 
Try Goutezol for 60 Days

People Said About Goutezol Gout Treatment
"I was only 30 when I got a gout attack. Goutezol really helped me to get over the attack in just two days and the ebook helps me with watching what I'm eating. My uncle have had gout problems too, so I recommended your product. Thanks a lot!" Matt, California
gout treatment


In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

SIDE EFFECTS

Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

 
 
     
 
 





Learn More about Natural Gout Remedy

You may or may not have heard about the MSM and gout connection, but MSM is being used for many conditions. Many of them are conditions that affect the joints much like gout does. MSM stands for Methyl Sulfonyl Methane - a natural sulfur compound. Though this is much like traditional sulfur, you will be glad to know that the smell normally associated with sulfur is not present when you use this...


A gout diet plan is an important part of controlling your gout symptoms and attacks. After all, when not controlled, gout can cause severe and permanent damage to your tissues, joints, and tendons. As gout is caused by high levels of uric acid in the blood, a proper gout diet plan should aim to reduce uric acid levels and encourage proper elimination of uric acid from the body. There are...


Recently, a gout and diet prevention study was published in by Dr. Hyon K. Choi and Gary Curhan in Arthritis Care & Research s June 2007 issue which examined the fact that, contrary to popular belief, coffee may not be as bad for gout sufferers as previously thought. Although gout patients have been told to stay away from coffee, there may be an ingredient in the beverage that can actually...


Foods that cause gout are rich in a chemical called purines. These foods include organ meats such as liver, brain, kidneys and sweetbreads. Other foods include anchovies, herring, dried peas and beans. The purines get converted to uric acid but if they accumulate in excess they will cause gout. The uric acid crystals, which form will irritate the lining of joints such as the one in the big...


Remember when you could sleep the whole night without a flare-up of gout? Do you remember what it was like to not have to wince with pain when you walk? Fortunately, gout is treatable and curable and these 6 suggestions will get you on the right path to treat your gout symptoms. How Gout Works Gout is characterized with excruciating pain in the joint at the base of...


prevention of kidney stones | levels of uric acid | kidney stone and pregnancy | how is gout diagnosed | diet for uric acid kidney stones | free home remedy for kidney stones | gout treatment symptoms diet | who gets gout | what is uric acid | purines food list |







 
 
 
 
 
 
 
(c) 2017 naturalremedygout.info
Contact Us | About Us | Privacy Policy | RSS Feed | Gout Sufferers